Rotigotine transdermal patch for the treatment of Parkinson's Disease.

Abstract

Rotigotine, a non-ergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMEA marketing authorization for the treatment of adult patients with early or advanced Parkinson's disease (PD) or with moderate to severe restless legs syndrome (RLS). FDA originally granted a marketing authorization for early PD, which was later suspended, and is now studying the authorization for RLS. The aim of this review is to review the pharmacokinetics, pharmacodynamics as well as the clinical efficacy and tolerability of the rotigotine transdermal patch in PD. Source material was identified using a PubMed search for the term 'rotigotine' and PD. Articles published up to January 2011 or abstract submitted to most relevant international neurology congresses were reviewed. The rotigotine transdermal patch is efficacious for the treatment of PD. Tolerability profile appears to be well within the range of that observed with other non-ergot dopamine agonists in PD. Application-site reactions were the most frequent adverse event, and they were considered mild to moderate in the majority of cases. The rotigotine transdermal patch offers a safe and efficacious alternative for the treatment of PD. Further studies should focus on the possibility that continuous dopamine stimulation by means of the transdermal patch has any influence on levodopa-related motor complications.

• Authors: Santiago Perez-Lloret, María Verónica Rey, Pietro Lucca Ratti, Olivier Rascol
• Journal: Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 27 Issue 1 Pg. 81-95 (Feb 2013) ISSN: 1472-8206 [Electronic] England
• PMID: 22320451 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2012 The Authors Fundamental and Clinical Pharmacology © 2012 Société Française de Pharmacologie et de Thérapeutique.

Chemical References

• Antiparkinson Agents
• Dopamine Agonists
• Tetrahydronaphthalenes
• Thiophenes
• rotigotine

Topics

• Animals
• Antiparkinson Agents (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Dopamine Agonists (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Humans
• Parkinson Disease (drug therapy)
• Tetrahydronaphthalenes (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Thiophenes (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Transdermal Patch