Fibroblast growth factor receptor 4 polymorphisms and susceptibility to coronary artery disease.

Abstract	Fibroblast growth factors (FGFs) and their receptors (FGFRs) play crucial roles in vascular smooth muscle cell proliferation and atherosclerosis and, therefore, may potentially affect the development of coronary artery disease (CAD). FGFR4 rs351855 (Gly388Arg) polymorphism has shown to be a risk factor for many diseases. The aim of this study was to investigate the association between FGFR4 polymorphisms and the susceptibility to CAD in the Chinese population. Two polymorphisms, rs351855 (Gly388Arg) and rs641101, were detected by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing in 687 CAD cases and 732 age-matched controls. Data were analyzed using the chi-square test. Results showed that frequencies of GA genotype, AA genotype, and A allele in rs351855 (Gly388Arg) polymorphism were significantly lower in CAD patients than in controls (odds ratio (OR)=0.78, 95% confidence intervals (CIs): 0.62-0.98, p=0.034; OR=0.58, 95% CI: 0.42-0.80, p=0.001; and OR=0.77, 95% CI: 0.66-0.90, p=0.001, respectively). The rs641101 polymorphism did not show any correlation with CAD. Haplotype analysis revealed that rs351855 and rs641101 AG haplotype also had lower frequency in CAD patients (OR=0.79, 95% CI: 0.67-0.92, p=0.002). Our data suggested that the FGFR4 rs351855 (Gly388Arg) polymorphism and AG haplotype (rs351855 and rs641101) could act as protective factors against CAD in the Chinese population and indicated that a single gene polymorphism could have diverse functions in different diseases.
Authors	Lan Ma, Haifeng Zhang, Carrie Han, Danian Tong, Meiyan Zhang, Yi'an Yao, Yu Luo, Xuebo Liu
Journal	DNA and cell biology (DNA Cell Biol) Vol. 31 Issue 6 Pg. 1064-9 (Jun 2012) ISSN: 1557-7430 [Electronic] United States
PMID	22313031 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
Chemical References	Receptor, Fibroblast Growth Factor, Type 4
Topics	Case-Control Studies Coronary Artery Disease (genetics, pathology) Female Gene Frequency (genetics) Genetic Predisposition to Disease (genetics) Humans Male Middle Aged Polymorphism, Single Nucleotide Receptor, Fibroblast Growth Factor, Type 4 (genetics)

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