Eccrine poromatosis associated with polychemotherapy.

Abstract

Eccrine poroma frequently occurs as a solitary tumour, and only a few reports have described the occurrence of multiple lesions. Multiple eccrine poromas, or eccrine poromatosis, may occur in patients who have undergone radiotherapy and/or polychemotherapy. We report here four cases of multiple eccrine poromas in patients who were either undergoing, or had undergone, intensive chemotherapy (from 6 months to 16 years prior to onset). Three patients had non-Hodgkin's lymphoma and one had malignant fibrous histiocytosis. The number of lesions varied from 3 to > 20 in each patient, and all the lesions occurred on non-irradiated skin. The histopathological features were consistent with those of eccrine poroma, Pinkus type. In addition to radiation therapy, intensive chemotherapy may play a role in the pathogenesis of multiple eccrine poromas even many years after treatment.

• Authors: Kazuyasu Fujii, Seiko Aochi, Chinatsu Takeshima, Masaki Ohtsuka, Toshihisa Hamada, Kenji Asagoe, Yumi Aoyama, Shin Morizane, Keiji Iwatsuki
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 92 Issue 6 Pg. 687-90 (Nov 2012) ISSN: 1651-2057 [Electronic] Sweden
• PMID: 22294042 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Biopsy
• Dermoscopy
• Female
• Histiocytoma, Malignant Fibrous (drug therapy)
• Humans
• Lymphoma, Non-Hodgkin (drug therapy)
• Male
• Middle Aged
• Poroma (chemically induced, pathology)
• Sweat Gland Neoplasms (chemically induced, pathology)
• Time Factors