Complex apocrine carcinoma with dominant myoepithelial proliferation in a dog.

Abstract

A rare case of complex apocrine carcinoma displaying dominant myoepithelial proliferation developed in the right leg subcutis of a 10-year-old male dog. The major cell population consisted of diffusely proliferating p63-expressing neoplastic cells that were largely myoepithelial in origin co-expressing α-smooth muscle actin. A small portion of the cell population consisted of concomitant basal epithelial cells lacking α-smooth muscle actin expression. The minor population consisted of p63-negative apocrine gland cells that expressed cytokeratin 8. The myoepithelial cell population showed a rather stronger proliferation activity than did the apocrine epithelial population. Thus, this tumor might have been derived from basal epithelial cells characterized by more predominant myoepithelial differentiation than luminal apocrine epithelial differentiation.

• Authors: Ayako Shiraki, Yuri Hojo, Takuma Tsuchiya, Liyun Wang, Takumi Ohishi, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 74 Issue 6 Pg. 801-4 (Jun 2012) ISSN: 1347-7439 [Electronic] Japan
• PMID: 22240986 (Publication Type: Case Reports, Journal Article)

Chemical References

• Actins
• Keratin-8

Topics

• Actins (metabolism)
• Animals
• Dog Diseases (pathology)
• Dogs
• Immunohistochemistry (veterinary)
• Keratin-8 (metabolism)
• Male
• Myoepithelioma (pathology, veterinary)
• Sweat Gland Neoplasms (pathology, veterinary)