Abstract | INTRODUCTION: To examine factors potentially contributing to premature cardiovascular disease mortality in African Americans (40% versus 20% all other populations), plasma homocysteine, serum vitamin B12 and folate levels were examined for African American participants in the Jackson Heart Study. METHODS: Of 5192 African American Jackson Heart Study participants (21-94 years), 5064 (mean age, 55 ± 13 years; 63% female) had homocysteine levels measured via fasting blood samples, with further assessments of participants' vitamin B12 (n = 1790) and folate (n = 1788) levels. Regression analyses were used to examine age, gender, vitamin B12 and folate with homocysteine levels. RESULTS: CONCLUSIONS: The results show that, as with other populations, age, gender, vitamin B12 and folate may predict homocysteine levels for African Americans. Diet may be an important predictive factor as well, given the relationships that were observed between plasma homocysteine and serum B vitamin levels.
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Authors | Olivia R Henry, Hamed Benghuzzi, Herman A Taylor Jr, Michelle Tucci, Kenneth Butler, Lynne Jones |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 344
Issue 2
Pg. 110-5
(Aug 2012)
ISSN: 1538-2990 [Electronic] United States |
PMID | 22173042
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Homocysteine
- Folic Acid
- Vitamin B 12
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Topics |
- Adult
- Black or African American
- Age Factors
- Aged
- Aged, 80 and over
- Cardiovascular Diseases
(blood, ethnology)
- Female
- Folic Acid
(blood)
- Homocysteine
(blood)
- Humans
- Linear Models
- Male
- Middle Aged
- Mississippi
- Sex Factors
- Vitamin B 12
(blood)
- Young Adult
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