Abstract |
A 55-year-old man with pulmonary Mycobacterium avium complex (MAC) disease was referred to our hospital with dyspnea on exertion and general fatigue. Chest computed tomography (CT) revealed a nodular shadow with pleural indentation in the left S(1+2), left pleural effusion, and a thick-walled cavitary lesion due to pulmonary MAC disease in the right S1. A biopsy specimen of the nodule in the left S(1+2) revealed adenocarcinoma, which various examinations confirmed to be stage IV lung adenocarcinoma (T2aN0M1a) complicated with active pulmonary MAC disease. Anti-non-tuberculous mycobacteriosis (NTM) chemotherapy consisting of rifampicin, ethambutol, clarithromycin and streptomycin was administered to treat the pulmonary MAC disease, and the lung cancer was then treated with 4 courses of carboplatin/ pemetrexed. This improved the patient's pulmonary MAC disease, and the lung cancer went into partial remission without severe adverse effects. Although a more detailed analysis of the drug interaction is required, we concluded that a combination of anti-NTM and carboplatin/ pemetrexed chemotherapy was safe and effective.
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Authors | Yu Fujita, Satoru Ishii, Satoshi Hirano, Yuichiro Takeda, Haruhito Sugiyama, Nobuyuki Kobayashi |
Journal | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
(Nihon Kokyuki Gakkai Zasshi)
Vol. 49
Issue 11
Pg. 855-60
(Nov 2011)
ISSN: 1343-3490 [Print] Japan |
PMID | 22171491
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Antitubercular Agents
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Topics |
- Antineoplastic Agents
(administration & dosage)
- Antitubercular Agents
(administration & dosage)
- Carcinoma, Non-Small-Cell Lung
(complications, drug therapy)
- Humans
- Lung Neoplasms
(complications, drug therapy)
- Male
- Middle Aged
- Mycobacterium avium-intracellulare Infection
(complications, drug therapy)
- Tuberculosis, Pulmonary
(complications, drug therapy)
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