Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF.

Abstract

Leukocytosis associated with secretion of granulocyte colony-stimulating factor (G-CSF) has been reported in various tumors, primarily poorly differentiated epithelial tumors, but is extremely rare in bone tumors. An 84-year-old woman experienced swelling and pain in the shoulder for 1 month. Leukocytosis and elevated serum G-CSF were observed, but resolved following tumor resection. A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically. Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF-secreting tumors.

• Authors: Takeaki Ishii, Akio Sakamoto, Shuichi Matsuda, Yoshihiro Matsumoto, Katsumi Harimaya, Yusuke Takahashi, Yoshinao Oda, Yukihide Iwamoto
• Journal: Skeletal radiology (Skeletal Radiol) Vol. 41 Issue 6 Pg. 719-23 (Jun 2012) ISSN: 1432-2161 [Electronic] Germany
• PMID: 22167228 (Publication Type: Case Reports, Journal Article)

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Aged, 80 and over
• Bone Neoplasms (blood, complications, diagnosis)
• Female
• Granulocyte Colony-Stimulating Factor (blood)
• Humans
• Humerus (diagnostic imaging, pathology)
• Leiomyosarcoma (blood, complications, diagnosis)
• Leukocytosis (blood, complications, diagnosis)
• Radiography