Influence of gestational age and reason for prior preterm birth on rates of recurrent preterm delivery.

Abstract

OBJECTIVE:

We sought to compare rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17-α-hydroxyprogesterone caproate (17P) with prior SPTB due to preterm labor (PTL) vs preterm premature rupture of membranes (PPROM).

STUDY DESIGN:

Women with singleton gestation having 1 prior SPTB enrolled at 16-24.9 weeks' gestation for weekly outpatient 17P administration were identified from a database. Rates of recurrent SPTB were compared between those with prior SPTB due to PTL or PPROM overall and by gestational age at prior SPTB.

RESULTS:

Records from 2123 women were analyzed. The prior PTL group vs the prior PPROM group experienced higher rates of recurrent SPTB at <37 weeks (29.7% vs 22.9%, P = .004), <35 weeks (14.0% vs 9.1%, P = .004), and <32 weeks (5.9% vs 3.3%, P = .024), respectively.

CONCLUSION:

Reason and gestational age of prior SPTB influence the likelihood of recurrent SPTB in women receiving 17P prophylaxis.

• Authors: Victor Hugo Gonzalez-Quintero, Yvette C Cordova, Niki B Istwan, Felipe Tudela, Debbie J Rhea, Letty Maria Romary, Adrian Marimon, Cheryl N Desch, Gary J Stanziano
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 205 Issue 3 Pg. 275.e1-5 (Sep 2011) ISSN: 1097-6868 [Electronic] United States
• PMID: 22071063 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Mosby, Inc. All rights reserved.

Chemical References

• Hydroxyprogesterones
• Progestins
• 17 alpha-Hydroxyprogesterone Caproate

Topics

• 17 alpha-Hydroxyprogesterone Caproate
• Adult
• Age Factors
• Female
• Fetal Membranes, Premature Rupture (drug therapy, etiology, prevention & control)
• Gestational Age
• Humans
• Hydroxyprogesterones (therapeutic use)
• Infant, Newborn
• Infant, Premature
• Pregnancy
• Premature Birth (drug therapy, etiology, prevention & control)
• Progestins (therapeutic use)
• Secondary Prevention