Langerhans cells histiocytosis with vulvar involvement and responding to thalidomide therapy--case report.

Abstract

Langerhans cell histiocytosis is a member of a group of rare histiocytic syndromes and is characterized for the proliferation of histiocytes called Langerhans'cells. Its manifestations vary from a solitary injury to systemic involvement, and vulvar lesions are uncommon. We describe a refractory case of cutaneous limited disease in a 57-year-old woman. She presented with a 6-year history of an erythematous papular eruption of the scalp, face, vulva, trunk and axillae. The diagnosis is difficult and in this case it was confirmed through immunohistochemical study and clinical improvement was achieved with thalidomide.

• Authors: Lana Bezerra Fernandes, Jackeline Gomes Guerra, Maurício Barcelos Costa, Isadora Guimarães Paiva, Fernanda Paglia Duran, Diogo Neves Jacó
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2011 Jul-Aug Vol. 86 Issue 4 Suppl 1 Pg. S78-81 ISSN: 1806-4841 [Electronic] Spain
• PMID: 22068778 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Thalidomide

Topics

• Facial Dermatoses (drug therapy, pathology)
• Female
• Histiocytosis, Langerhans-Cell (drug therapy, pathology)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Middle Aged
• Scalp Dermatoses (drug therapy, pathology)
• Skin Diseases (drug therapy, pathology)
• Thalidomide (therapeutic use)
• Vulvar Diseases (drug therapy, pathology)