Abstract | BACKGROUND: METHODS: Between 1991 and 2009, 34 ILPs were performed in patients with irresectable STS of the wrist, hand, ankle, or foot. Disease was unifocal in 21 (62%) patients. RESULTS: Overall response rate was 71% (n = 24). After a median follow-up of 34 (range 1-143) months the local recurrence rate was 32%. Amputation was unavoidable in four patients (13%), four other patients (13%) underwent a partial amputation of the hand or foot. CONCLUSION: With a limb salvage rate of 87%, TM-ILP is an effective treatment modality in patients with distal STS. In all patients with an indication for amputation surgery due to an STS in the distal part of the limb, TM-ILP should be considered.
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Authors | Jan P Deroose, Albertus N van Geel, Jacobus W A Burger, Alexander M M Eggermont, Cornelis Verhoef |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 105
Issue 6
Pg. 563-9
(May 2012)
ISSN: 1096-9098 [Electronic] United States |
PMID | 22020863
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Wiley Periodicals, Inc. |
Chemical References |
- Antineoplastic Agents, Alkylating
- Tumor Necrosis Factor-alpha
- Melphalan
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amputation, Surgical
(statistics & numerical data)
- Antineoplastic Agents, Alkylating
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Cancer, Regional Perfusion
- Disease Progression
- Extremities
- Humans
- Limb Salvage
- Male
- Melphalan
(administration & dosage)
- Middle Aged
- Neoplasm Recurrence, Local
- Sarcoma
(drug therapy, mortality)
- Soft Tissue Neoplasms
(drug therapy, mortality)
- Tumor Necrosis Factor-alpha
(administration & dosage)
- Young Adult
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