[A resected case of locally invasive rectal cancer successfully treated with neoadjuvant capecitabine, oxaliplatin, bevacizumab and radiation therapy].

Abstract

A 57-year-old man was admitted to our hospital with a complaint of perineal pain. He was diagnosed as advanced rectal cancer with an invasion of prostate, and we conducted neoadjuvant capecitabine, oxaliplatin, bevacizumab and radiation therapy. After chemoradiation therapy, the tumor regressed to an ulcerative lesion without invasion of the prostate. Abdominoperineal resection was then performed without radical resection. The tumor regressed to an ulcer and only a few cancer cells were detected in the submucosal layer pathologically.

• Authors: Shunji Suzuki, Nobuyuki Shigaki, Sachio Yokoyama, Hiroya Yamashita, Hiroki Sugita, Nobuyuki Arima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 9 Pg. 1545-7 (Sep 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21918360 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Organoplatinum Compounds
• Oxaliplatin
• Deoxycytidine
• Bevacizumab
• Capecitabine
• Fluorouracil

Topics

• Antibodies, Monoclonal (administration & dosage, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bevacizumab
• Capecitabine
• Deoxycytidine (administration & dosage, analogs & derivatives, therapeutic use)
• Fluorouracil (administration & dosage, analogs & derivatives, therapeutic use)
• Humans
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Invasiveness
• Organoplatinum Compounds (administration & dosage, therapeutic use)
• Oxaliplatin
• Rectal Neoplasms (drug therapy, pathology, radiotherapy, surgery)
• Tomography, X-Ray Computed