[An extremely high serum methotrexate concentration associated with acute renal failure in a patient with acute lymphoblastic leukemia after conduction of high dose consolidation].

Abstract

Acute renal failure (ARF) is one of rare and severe methotrexate (MT)-induced complications in patients with acute lymphoblastic leukemia. A case of MT-induced renal dysfunction with an extremely high serum MT concentration is reported. This toxicity required conduction of hemodiafiltration for extracorporeal MT elimination. The presence of homozygous mutation of methylene-tetrahydrofolate reductase reflects an individual metabolism of MT and its renal clearance.

• Authors: M A Pimenova, A N Sokolov, L S Biriukova, E N Ustinova, I I Shaforostova, I A Donskova, R F Bogdanov, E N Parovichnikova, V G Savchenko
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 83 Issue 7 Pg. 58-61 ( 2011) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 21894753 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Leucovorin
• Methotrexate

Topics

• Acute Kidney Injury (chemically induced, diagnosis, prevention & control)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, blood, therapeutic use)
• Dose-Response Relationship, Drug
• Humans
• Kidney Function Tests
• Leucovorin (administration & dosage, therapeutic use)
• Male
• Methotrexate (adverse effects, blood, therapeutic use)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (blood, drug therapy)
• Remission Induction