Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y tetanus toxoid conjugate vaccine for infants and toddlers.

Abstract

The highest rates of invasive meningococcal disease occur in children under 2 years of age, yet as of early 2011 no vaccine was licensed for the youngest infants. However, a novel vaccine consisting of capsular polysaccharides from Haemophilus influenzae type b (Hib) and Neisseria meningitidis serogroups C and Y conjugated to tetanus toxoid (HibMenCY-TT; MenHibrix, GlaxoSmithKline) is in the late stages of development. In clinical trials involving more than 7800 children, HibMenCY-TT was shown to be safe and immunogenic when administered at 2, 4, 6 and 12-15 months of age. Anti-polyribosylribitol phosphate antibody responses were noninferior to those elicited by licensed monovalent Hib vaccines, and most vaccinees developed bactericidal antibodies against N. meningitidis serogroups C and Y. The majority of subjects retained antibody responses as far as 3 years after vaccination. If licensed, HibMenCY-TT not only represents an incremental option for protection against invasive Hib, but also has the potential to prevent invasive meningococcal disease without increasing the number of injections.

• Authors: Kristina A Bryant, Gary S Marshall
• Journal: Expert review of vaccines (Expert Rev Vaccines) Vol. 10 Issue 7 Pg. 941-50 (Jul 2011) ISSN: 1744-8395 [Electronic] England
• PMID: 21806393 (Publication Type: Journal Article, Review)

Chemical References

• Haemophilus Vaccines
• Hib-MenCY-TT vaccine
• Meningococcal Vaccines
• Polysaccharides, Bacterial
• Tetanus Toxoid
• Vaccines, Combined
• Vaccines, Conjugate

Topics

• Haemophilus Vaccines (adverse effects, immunology)
• Haemophilus influenzae type b (drug effects, immunology)
• Humans
• Infant
• Infant, Newborn
• Meningococcal Vaccines (administration & dosage, adverse effects, immunology, therapeutic use)
• Polysaccharides, Bacterial (adverse effects, immunology)
• Tetanus Toxoid (administration & dosage, adverse effects, immunology, therapeutic use)
• Vaccines, Combined (administration & dosage, adverse effects, immunology, therapeutic use)
• Vaccines, Conjugate (administration & dosage, adverse effects, immunology, therapeutic use)