Psychological distress in men with prostate cancer receiving adjuvant androgen-deprivation therapy.

Abstract

OBJECTIVES:

To compare the occurrence of depression, anxiety, self body image perception, sleep disturbances, and diminished quality of life in prostate cancer patients undergoing adjuvant androgen-deprivation therapy (ADT) as opposed to patients in follow-up alone.

METHODS AND MATERIALS:

Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index, Restless Legs Syndrome Study Group essential diagnostic criteria, Body Image Scale and Functional Assessment of Cancer Therapy Prostate were administered to consecutive prostate cancer patients who underwent radical prostatectomy or radiation therapy and are presently either under adjuvant ADT or included in a follow-up program.

RESULTS:

Of the 103 patients enrolled, 49 (47.6%) were receiving adjuvant ADT and 54 (52.4%) were not. Compared with the controls, the patients undergoing ADT showed higher levels of depression (P = 0.002), worse self body image perception (P = 0.001), worse quality of life (P = 0.0001) and worse sleep quality (P = 0.04). ADT was significantly associated with depression at multivariate analysis after adjustment for age, stage, Gleason score, as well as demographic and social variables (P = 0.001). Depression scores showed a strong inverse correlation with quality of life scores (P < 0.01).

CONCLUSIONS:

Adjuvant ADT is associated with depression, worse quality of life, and altered self body image in prostate cancer patients.

• Authors: Andrea Saini, Alfredo Berruti, Cecilia Cracco, Erica Sguazzotti, Francesco Porpiglia, Lucianna Russo, Valentina Bertaglia, Rocco Luigi Picci, Manuela Negro, Alessandra Tosco, Sara Campagna, Roberto Mario Scarpa, Luigi Dogliotti, Pier Maria Furlan, Luca Ostacoli
• Journal: Urologic oncology (Urol Oncol) Vol. 31 Issue 3 Pg. 352-8 (Apr 2013) ISSN: 1873-2496 [Electronic] United States
• PMID: 21803612 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Androgen Antagonists
• Prostate-Specific Antigen

Topics

• Aged
• Aged, 80 and over
• Androgen Antagonists (adverse effects)
• Anxiety (chemically induced)
• Body Image (psychology)
• Depression (chemically induced)
• Humans
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Grading
• Outcome Assessment, Health Care
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (drug therapy, pathology, psychology)
• Quality of Life (psychology)
• Sleep Wake Disorders (chemically induced)
• Stress, Psychological (etiology)