Nanoparticle formulation for controlled release of capsaicin.
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| Abstract |
Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162 +/- 3 nm to 153 +/- 3 nm and in drug loading efficiency from 25% to 20% were observed, whereas the drug release period was significantly changed from 11 days for 1:2 to 5 days for 1:5 ratio. To get a more sustained release, a modified single emulsion method was applied with three kinds of biocompatible polymers (PLLA, PLGA, and PCL). Among them, PLLA particles showed a much sustained release profile than PLGA or PCL ones with the similar size. For PLLA particles, particles size and drug encapsulation efficiency increased as the oil/water ratio decreased, and the bigger particles showed the slower release profiles as well as the higher drug-loading efficiency, thus about 1 month release was obtained with 800 nm particles. In conclusion, formulation for the controlled release of capsaicin from 1 week to 1 month was prepared by using biocompatible nanoparticles.
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| Authors | Seon Kim, Jong Chul Kim, Donggeun Sul, Sun Wook Hwang, Sang Heon Lee, Young Ha Kim, Giyoong Tae |
| Journal | Journal of nanoscience and nanotechnology (J Nanosci Nanotechnol) Vol. 11 Issue 5 Pg. 4586-91 (May 2011) ISSN: 1533-4880 [Print] United States |
| PMID | 21780502 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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