Evaluation of long-term clarithromycin treatment in adult Chinese Patients with chronic rhinosinusitis without nasal polyps.

Abstract

OBJECTIVE:

To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP).

METHODS:

Thirty-three CRSnNP patients were enrolled and subjected to CAM treatment for 12 weeks (250 mg daily). The total nasal symptom scores (TNSS), nasal resistance and inflammatory mediators including interleukin (IL)-8 and myeloperoxidase (MPO) were evaluated at weeks 0 and 12. Quality of life (QoL) was assessed in all patients by using the Sinonasal Outcome Test 20 and Short Form 36 questionnaires.

RESULTS:

CAM treatment significantly improved TNSS, nasal resistance and QoL, and it inhibited IL-8 and MPO production in CRSnNP patients (p < 0.05). CAM treatment was more effective for IL-8(high) CRSnNP patients than for IL-8(low) CRSnNP patients (p < 0.05).

CONCLUSION:

Long-term, low-dose CAM treatment is effective and safe for the treatment of CRSnNP in Chinese patients.

• Authors: Qing Luo, Fenghong Chen, Wenlong Liu, Zuwang Li, Rui Xu, Yunping Fan, Rong Chen, Yu Xu, Zheng Liu, Geng Xu, Qingling Fu, Kejun Zuo, Jianbo Shi, Huabin Li, Nasal Health Group, China (NHGC)
• Journal: ORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 73 Issue 4 Pg. 206-11 ( 2011) ISSN: 1423-0275 [Electronic] Switzerland
• PMID: 21757966 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 S. Karger AG, Basel.

Chemical References

• Anti-Bacterial Agents
• Clarithromycin

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• China (epidemiology)
• Chronic Disease
• Clarithromycin (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• Male
• Nasal Polyps
• Prevalence
• Rhinitis (complications, drug therapy, epidemiology)
• Sinusitis (complications, drug therapy, epidemiology)
• Time Factors
• Treatment Outcome