Thyroid functions in long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy and radiotherapy.

Abstract

OBJECTIVE:

Post-treatment endocrine disturbances are common in cancer patients who have received radiotherapy or chemotherapy. The objective of this study was to evaluate the thyroid functions of long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy and radiotherapy.

METHODS:

Thyroid functions of 55 Hodgkin's lymphoma patients (M/F:2.05/1) in complete remission were evaluated retrospectively.

RESULTS:

The mean age of the patients at diagnosis was 10.35±4.09 (range: 2.83-17) years and the mean follow-up period was 5.54±3.68 (range: 0.92-13.92) years. All patients received chemotherapy; a total of 50 patients (90.9%) underwent radiotherapy, 42 (76.4%) of whom received neck/mantle radiotherapy. Thyroid function tests were abnormal in 14 (24.5%) patients and normal - in the remaining 41 (74.5%). A diagnosis of subclinical and overt hypothyroidism was made in 11 (78.6%) and 3 (21.4%) patients with abnormal thyroid function tests, respectively. Nearly one-fourth (21.4%) of all thyroid function disorders were detected in the first year of follow-up. A statistically significant correlation was found between the dose of mantle radiotherapy and thyroid function disorder (p=0.002). In addition, statistically significant correlations were established between thyroid examination or thyroid ultrasonography findings and thyroid functions (p <0.001 or p=0.006, respectively).

CONCLUSIONS:

Radiation-induced thyroid disorders may develop in pediatric Hodgkin's lymphoma patients in complete remission starting as early as the first year after treatment and are dose-dependent. Patients, particularly those who have been exposed to radiotherapy of the neck, must be followed up closely for occurrence of thyroid dysfunctions.

• Authors: Metin Demirkaya, Betül Sevinir, Halil Sağlam, Lütfi Özkan, Okan Akacı
• Journal: Journal of clinical research in pediatric endocrinology (J Clin Res Pediatr Endocrinol) Vol. 3 Issue 2 Pg. 89-94 ( 2011) ISSN: 1308-5735 [Electronic] Turkey
• PMID: 21750638 (Publication Type: Journal Article)
• Copyright: ©Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Child
• Child, Preschool
• Combined Modality Therapy
• Female
• Hodgkin Disease (drug therapy, physiopathology, radiotherapy)
• Humans
• Male
• Radiation Injuries (etiology)
• Remission Induction
• Retrospective Studies
• Thyroid Function Tests
• Thyroid Gland (drug effects, physiopathology, radiation effects)
• Thyroid Nodule (etiology)
• Turkey