Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents.

Abstract

CONCLUSION:

Imaging of the endolymphatic space was possible in most cases after administering a standard dose of gadolinium (Gd) by using heavily T2-weighted 3D fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) magnetic resonance imaging (MRI).

OBJECTIVES:

The aim of this study was to characterize the contrast enhancement in the inner ear after intravenous injection of Gd and to compare the signal intensity after a double dose or standard dose of Gd.

METHODS:

We injected a standard dose of gadodiamide hydrate (DTPA-BMA) or a double dose of gadoteridol (HP-DO3A) intravenously in patients affected by Meniere's disease and performed hT(2)W-3D-FLAIR 3 T MRI. Contrast enhancement of the basal turn of the cochlea was evaluated semiquantitatively.

RESULTS:

Endolymphatic hydrops was observed in the cochlea and vestibule of the affected ears of patients with Meniere's disease in both the double-dose group and the standard-dose group.

• Authors: Hirokazu Suzuki, Masaaki Teranishi, Michihiko Sone, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 131 Issue 10 Pg. 1025-31 (Oct 2011) ISSN: 1651-2251 [Electronic] England
• PMID: 21732744 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Heterocyclic Compounds
• Organometallic Compounds
• gadoteridol
• gadodiamide
• Gadolinium
• Gadolinium DTPA

Topics

• Adult
• Contrast Media (administration & dosage)
• Female
• Gadolinium (administration & dosage)
• Gadolinium DTPA (administration & dosage)
• Heterocyclic Compounds (administration & dosage)
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Meniere Disease (pathology)
• Middle Aged
• Organometallic Compounds (administration & dosage)
• Perilymph
• Young Adult