Abstract |
Polygonum cuspidatum (PC) has been used for the treatment of arthritis and urinary diseases in traditional medicine. Despite recent evidence that PC has anti-oxidant, anti-tumoral, and anti-inflammatory effects, analgesic and anti-inflammatory effects of PC have not been elucidated yet in vivo. Thus, in the present study, analgesic and anti-inflammatory effects of ethyl acetate extract of PC (EAPC) were investigated in vivo for the first time. Hot plate test and tail-flick test revealed that EAPC at 200 mg/kg exerts analgesic effect (p < 0.05). In contrast, EAPC did not show significant analgesic effect in acetic acid-induced writhing test. Serotonin-induced paw edema model and Freund's complete adjuvant (FCA)-induced adjuvant arthritis model were used to examine anti-inflammatory effect of EAPC in vivo. In serotonin-induced paw edema model, EAPC suppressed swelling inflammatory response within 12 min after serotonin injection, at both 100- and 200-mg/kg dose (p < 0.05). Consistently, in FCA-induced adjuvant arthritis model, FCA at 200 mg/kg significantly suppressed FCA-induced joint swelling within 3 days (p < 0.05), whereas FCA at 100 mg/kg showed the similar result within 5 days (p < 0.05). Furthermore, EAPC effectively inhibited positive responses of c-reactive protein and rheumatoid factor compared to untreated control. Taken together, our findings suggest that EAPC can be a potent candidate for rheumatoid arthritis treatment.
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Authors | Jong-Hyun Han, Wonil Koh, Hyo-Jung Lee, Hyo-Jeong Lee, Eun-Ok Lee, Soo Jin Lee, Jae-Ho Khil, Jung Tae Kim, Soo-Jin Jeong, Sung-Hoon Kim |
Journal | Immunopharmacology and immunotoxicology
(Immunopharmacol Immunotoxicol)
Vol. 34
Issue 2
Pg. 191-5
(Apr 2012)
ISSN: 1532-2513 [Electronic] England |
PMID | 21711083
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Analgesics
- Anti-Inflammatory Agents
- Drugs, Chinese Herbal
- Serotonin
- ethyl acetate
- C-Reactive Protein
- Freund's Adjuvant
- Rheumatoid Factor
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Topics |
- Acetates
(chemistry)
- Analgesics
(isolation & purification, pharmacology, therapeutic use)
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology, therapeutic use)
- Arthritis, Experimental
(blood, chemically induced, pathology, prevention & control)
- C-Reactive Protein
(metabolism)
- Drugs, Chinese Herbal
(isolation & purification, pharmacology, therapeutic use)
- Edema
(chemically induced, pathology, prevention & control)
- Fallopia japonica
(chemistry)
- Freund's Adjuvant
(pharmacology)
- Inflammation
(chemically induced, pathology, prevention & control)
- Medicine, Korean Traditional
- Mice
- Mice, Inbred ICR
- Pain Measurement
(methods)
- Phytotherapy
(methods)
- Rats
- Rats, Sprague-Dawley
- Reaction Time
(drug effects)
- Rheumatoid Factor
(blood)
- Serotonin
(pharmacology)
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