Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.

Abstract

Glycerylphosphorylcholine (GPC) phosphocholine phosphodiesterase activity (EC 3.1.4.38) is significantly reduced in multiple sclerosis plaques compared to adjacent tissue with a P less than 0.01 based upon the Student-Newman-Keuls or Tukey test. This finding is in accord with the proposal that this particular form of the enzyme is myelin-specific. Similar activities for GPC phosphocholine phosphodiesterase were obtained with samples from various regions of the same individual brain.

• Authors: L Janzen, W W Tourtellotte, J N Kanfer
• Journal: Experimental neurology (Exp Neurol) Vol. 109 Issue 2 Pg. 243-6 (Aug 1990) ISSN: 0014-4886 [Print] United States
• PMID: 2165915 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2',3'-Cyclic-Nucleotide Phosphodiesterases
• Phosphoric Diester Hydrolases
• 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
• CNP protein, human
• glycerophosphocholine cholinephosphodiesterase

Topics

• 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
• 2',3'-Cyclic-Nucleotide Phosphodiesterases (metabolism)
• Aged
• Analysis of Variance
• Humans
• Middle Aged
• Multiple Sclerosis (enzymology, pathology)
• Myelin Sheath (enzymology, pathology)
• Phosphoric Diester Hydrolases (metabolism)