Abstract |
The L/ N-type calcium channel blocker cilnidipine has unique effects including sympathetic nerve suppression and the balanced vasodilatation of arteries and veins that may alleviate morning hypertension ( MHT) or peripheral edema caused by calcium channel antagonists. We used ambulatory blood pressure monitoring (ABPM) and a unique peripheral edema measurement to evaluate the effect of morning and bedtime cilnidipine in patients with MHT. Forty-three patients with MHT (60 ± 12 years) were randomly assigned to a morning or bedtime cilnidipine (10-20 mg/day). MHT was defined as a mean systolic blood pressure (SBP) ≥ 135 mm Hg by ABPM within 2 hours after awaking. After 3 months, greater SBP reductions were observed in the bedtime administration group (versus the morning administration group) at 3:30-6:00 AM (-24 ± 20 mm Hg vs. -10 ± 4 mm Hg; P < .05) and at 6:30-9:00 AM (-26 ± 15 mm Hg vs. -14 ± 17 mm Hg; P < .05). Although physical examinations showed leg edema in 16% of the patients, quantitative evaluations did not reveal significant volume gains. Cilnidipine had a greater effect on MHT, without causing significant leg edema, when administered at bedtime.
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Authors | Sumito Narita, Yasuko Yoshioka, Atsumi Ide, Toshiaki Kadokami, Hidetoshi Momii, Masayoshi Yoshida, Shin-ichi Ando |
Journal | Journal of the American Society of Hypertension : JASH
(J Am Soc Hypertens)
2011 Sep-Oct
Vol. 5
Issue 5
Pg. 410-6
ISSN: 1933-1711 [Print] United States |
PMID | 21640687
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2011 American Society of Hypertension. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Calcium Channel Blockers
- Dihydropyridines
- cilnidipine
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Topics |
- Aged
- Blood Pressure
(drug effects)
- Blood Pressure Monitoring, Ambulatory
- Calcium Channel Blockers
(pharmacology)
- Dihydropyridines
(pharmacology)
- Edema
(prevention & control)
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(complications, prevention & control)
- Leg
- Male
- Middle Aged
- Sympathetic Nervous System
(physiopathology)
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