Efficacy and safety of pitavastatin in Japanese patients with hypercholesterolemia: LIVES study and subanalysis.

Abstract

The Livalo Effectiveness and Safety (LIVES) study was an observational study to examine the efficacy and safety of pitavastatin, a newly developed drug, in approximately 20,000 Japanese patients with hypercholesterolemia. During a 2-year follow-up period, no significant problems concerning safety were observed upon treatment with pitavastatin. Pitavastatin demonstrated potent and stable lowering of the LDL-cholesterol level. The LIVES study subanalyses revealed significant and continuous elevation of HDL-cholesterol in association with pitavastatin treatment and also showed that the drug did not adversely affect glycemic control as evaluated by the glycohemoglobin A(1c) level. Moreover, pitavastatin treatment was associated with an increase in estimated glomerular filtration rate in subjects with chronic kidney disease. These results suggest the usefulness of pitavastatin in hypercholesterolemic patients from various backgrounds. The ongoing LIVES study extension is expected to provide further data on cardiovascular outcome in subjects treated with pitavastatin.

• Authors: Koutaro Yokote, Hitoshi Shimano, Mitsuyoshi Urashima, Tamio Teramoto
• Journal: Expert review of cardiovascular therapy (Expert Rev Cardiovasc Ther) Vol. 9 Issue 5 Pg. 555-62 (May 2011) ISSN: 1744-8344 [Electronic] England
• PMID: 21615316 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Glycated Hemoglobin A
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Quinolines
• hemoglobin A1c protein, human
• pitavastatin

Topics

• Aged
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Diabetes Complications (physiopathology)
• Female
• Follow-Up Studies
• Glomerular Filtration Rate (drug effects)
• Glycated Hemoglobin (analysis)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use)
• Hypercholesterolemia (blood, complications, drug therapy)
• Japan
• Male
• Middle Aged
• Quinolines (adverse effects, therapeutic use)
• Renal Insufficiency (complications, physiopathology)