Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients.

Abstract

Lymphoblastoid cell lines established from patients suffering from bipolar manic-depressive psychosis or from a control group have been used to study the metabolism of the polyphosphoinositides in these cells. Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporation into the mono-, di- and triphosphoinositides was measured after extracting the water- and lipid-soluble inositol-containing pools. Although both the uptake of inositol and the 'free' intracellular inositol pool sizes were similar in the two cell groups, the incorporation of [3H]inositol into the phosphoinositides of the cells derived from bipolar manic-depressives was significantly less (by around 50-60%) than that which occurred in the control cells.

• Authors: R E Banks, J F Aiton, G Cramb, G J Naylor
• Journal: Journal of affective disorders (J Affect Disord) Vol. 19 Issue 1 Pg. 1-8 (May 1990) ISSN: 0165-0327 [Print] Netherlands
• PMID: 2161438 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphatidylinositols
• Inositol

Topics

• Bipolar Disorder (genetics, metabolism)
• Cell Line
• Female
• Humans
• Inositol (metabolism)
• Lymphocytes (metabolism)
• Male
• Middle Aged
• Phosphatidylinositols (metabolism)
• Risk Factors