Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus.

Abstract

A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

• Authors: Dipanjan Pan, Shelton D Caruthers, Angana Senpan, Ceren Yalaz, Allen J Stacy, Grace Hu, Jon N Marsh, Patrick J Gaffney, Samuel A Wickline, Gregory M Lanza
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 133 Issue 24 Pg. 9168-71 (Jun 22 2011) ISSN: 1520-5126 [Electronic] United States
• PMID: 21599030 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Colloids
• Contrast Media
• Oleic Acid
• Copper

Topics

• Animals
• Colloids
• Contrast Media (chemical synthesis, metabolism, pharmacokinetics)
• Copper (chemistry)
• Humans
• Magnetic Resonance Imaging (methods)
• Nanostructures (chemistry)
• Oleic Acid (chemistry)
• Rats
• Thrombosis (diagnosis, metabolism)