HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

Abstract
Amiloride.HCl is clinically used as an oral potassium-sparing diuretic, but multiple studies in biochemical, cellular and animal models have shown that the drug also possesses anti-tumour and anti-metastasis activities. The additional effects appear to arise through inhibition of two discrete targets: (i) the sodium-hydrogen exchanger 1 (NHE1), a membrane protein responsible for the characteristically low extracellular pH of tumours and (ii) the urokinase-type plasminogen activator (uPA), a serine protease mediator of cell migration, invasion and metastasis and well-known marker of poor prognosis in cancer. This mini-review summarises for the first time the reported anti-tumour/metastasis effects of amiloride in experimental models, discusses the putative molecular mechanisms responsible for these effects and concludes by commenting on the pros and cons of trialling amiloride or one of its structural analogues as potential new anti-tumour/metastasis drugs.
AuthorsHayden Matthews, Marie Ranson, Michael J Kelso
JournalInternational journal of cancer (Int J Cancer) Vol. 129 Issue 9 Pg. 2051-61 (Nov 01 2011) ISSN: 1097-0215 [Electronic] United States
PMID21544803 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2011 UICC.
Chemical References
  • Antineoplastic Agents
  • Sodium Channel Blockers
  • Sodium-Hydrogen Exchangers
  • Amiloride
  • Urokinase-Type Plasminogen Activator
Topics
  • Administration, Oral
  • Amiloride (administration & dosage, pharmacology, therapeutic use)
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacology, therapeutic use)
  • Disease Models, Animal
  • Humans
  • Neoplasm Metastasis (drug therapy)
  • Neoplasms (drug therapy)
  • Sodium Channel Blockers (administration & dosage, pharmacology, therapeutic use)
  • Sodium-Hydrogen Exchangers (antagonists & inhibitors)
  • Urokinase-Type Plasminogen Activator (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: