Anticancer effects of novel photodynamic therapy with glycoconjugated chlorin for gastric and colon cancer.

Abstract

BACKGROUND/AIM:

Photodynamic therapy (PDT) is an attractive, minimally invasive modality for cancer therapy that utilizes the interaction of light and photosensitizer. To improve the efficacy of PDT, development of cancer specificity of the photosensitizer is needed. Cancer cells consume more glucose than normal cells. In this study, the efficacy of PDT using a newly developed photosensitizer, glycoconjugated chlorin (H2TFPC-SGlc), was compared with Talaporfin, which is clinically used in Japan.

MATERIALS AND METHODS:

Photosensitizers were administered to gastric and colon cancer cell lines, followed by irradiation of light, and the cell death-inducing effects were compared. Xenograft tumor mouse models were established and photosensitizer accumulation was assessed and antitumor effects analyzed.

RESULTS:

In vitro, H(2)TFPC-SGlc was 30 times more cytotoxic to cancer cells than was Talaporfin. In vivo, H(2)TFPC-SGlc accumulation was higher in xenograft tumors and significantly suppressed tumor growth when compared with Talaporfin.

CONCLUSION:

This novel glycoconjugated chlorin is potentially useful in PDT.

• Authors: Mamoru Tanaka, Hiromi Kataoka, Motoshi Mabuchi, Shiho Sakuma, Satoru Takahashi, Ryoto Tujii, Haruo Akashi, Hiromi Ohi, Shigenobu Yano, Akimichi Morita, Takashi Joh
• Journal: Anticancer research (Anticancer Res) Vol. 31 Issue 3 Pg. 763-9 (Mar 2011) ISSN: 1791-7530 [Electronic] Greece
• PMID: 21498693 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Glycoconjugates
• Photosensitizing Agents
• Porphyrins
• Reactive Oxygen Species
• chlorin

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology, therapeutic use)
• Cell Death (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Colonic Neoplasms (drug therapy, pathology)
• Glycoconjugates (chemistry, pharmacology, therapeutic use)
• Humans
• Inhibitory Concentration 50
• Mice
• Mice, Nude
• Photochemotherapy
• Photosensitizing Agents (chemistry, pharmacology, therapeutic use)
• Porphyrins (chemistry, pharmacology, therapeutic use)
• Reactive Oxygen Species (metabolism)
• Stomach Neoplasms (drug therapy, pathology)
• Xenograft Model Antitumor Assays