Abstract | OBJECTIVE: To determine the impact of p53 overexpression on tumor recurrence after bacillus Calmette-Guérin (BCG) intravesical therapy in patients with nonmuscle invasive bladder cancer ( NMIBC). METHODS: Between January 1999 and December 2008, 275 patients who received six BCG intravesical instillations for NMIBC ( transitional cell carcinoma) after transurethral resection were assessed for differences in outcomes according to the level of p53 overexpression. A multivariate logistic regression model was applied to assess the predictive capacity of variables for recurrence. Overexpression of p53 was determined using monoclonal p53-DO7 antibody. RESULTS: In 275 subjects, the recurrence rate was higher based on the level of p53 expression (p = 0.019). Based on multivariate analysis, a strong-positive p53 >60% (p = 0.031) and tumor grade (p = 0.015) were significant predictors for recurrence. Patients with a strong-positive p53 >60% had a much lower 5-year biochemical recurrence-free survival rate than patients with p53 ≤60% (72.1 vs. 31.5%, p < 0.001). CONCLUSIONS: Strong overexpression of p53 was predictive of recurrence in patients with NMIBC undergoing intravesical BCG treatment. A 6-week induction course of BCG alone is not sufficient to prevent recurrence in patients with NMIBC with high p53 expression; additional prophylactic strategies are needed for these patients.
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Authors | Jong Jin Oh, Sang Hyun Ji, Don Kyoung Choi, In Hyuk Gong, Tae Heon Kim, Dong Soo Park |
Journal | Oncology
(Oncology)
Vol. 79
Issue 5-6
Pg. 440-6
( 2010)
ISSN: 1423-0232 [Electronic] Switzerland |
PMID | 21487231
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Aged
- BCG Vaccine
(administration & dosage, therapeutic use)
- Carcinoma, Transitional Cell
(genetics, pathology, therapy)
- Female
- Gene Expression
- Genes, p53
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(prevention & control)
- Neoplasm Staging
- Treatment Outcome
- Urinary Bladder Neoplasms
(genetics, pathology, therapy)
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