Development and characterization of doxorubicin loaded microparticles against experimental visceral leishmaniasis.

Abstract

Visceral leishmaniasis (VL) is the most severe of all the forms of leishmaniasis and usually lethal if untreated. The present work aimed to develop and characterize doxorubicin loaded mannan conjugated microparticles against experimental visceral leishmaniasis for selective and targeted delivery of doxorubicin to the macrophages of liver and spleen for the effective chemotherapy of VL. Macrophage targeting using doxorubicin loaded PLGA-microparticles would certainly improve the chemotherapy with reduced side effects against VL.

• Authors: Sheeshpal Sharma, Pankaj Kumar, Anil Jaiswal, Anuradha Dube, Swati Gupta
• Journal: Journal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 7 Issue 1 Pg. 135-6 (Feb 2011) ISSN: 1550-7033 [Print] United States
• PMID: 21485839 (Publication Type: Journal Article)

Chemical References

• Capsules
• Drug Carriers
• Doxorubicin

Topics

• Capsules
• Cell Survival (drug effects)
• Doxorubicin (administration & dosage, chemistry)
• Drug Carriers (chemical synthesis)
• Leishmania (drug effects, physiology)