Abstract | OBJECTIVE: Dietary-supplemented arginine has been shown to have positive effects on cardiovascular disease, but several drawbacks exist and could potentially be avoided by using L- citrulline, since it is recycled to L-arginine. However, citrulline is very rapidly metabolized. We therefore developed a sustained-release form of citrulline and evaluated its metabolic behavior in rats. METHODS: Male Sprague Dawley rats were divided into three groups: receiving "empty microcapsule" (control group), 1 g/kg/d immediate-release citrulline (IR citrulline group), or 1 g/kg/d sustained-release citrulline (SR citrulline group). Citrulline was given each day at 9 a.m. after blood samples for 9 d, and on day 10, blood samples were drawn every 4 h to study the decrease in plasma amino acid concentrations. RESULTS: CONCLUSION: This experimental study provides a strong rationale for using this new formulation for atherosclerosis treatment.
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Authors | Marie-Clotilde Berthe, Sylviane Darquy, Charlotte Breuillard, Lynda Lamoudi, Julie Marc, Luc Cynober, Jean-Claude Chaumeil, Rémy Couderc |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
2011 Nov-Dec
Vol. 27
Issue 11-12
Pg. 1168-71
ISSN: 1873-1244 [Electronic] United States |
PMID | 21482070
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Delayed-Action Preparations
- Citrulline
- Nitric Oxide
- Arginine
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Topics |
- Animals
- Arginine
(blood)
- Cardiovascular Diseases
(drug therapy, pathology)
- Citrulline
(administration & dosage, blood)
- Delayed-Action Preparations
(metabolism)
- Dietary Supplements
- Dose-Response Relationship, Drug
- Hyperargininemia
(drug therapy, pathology)
- Male
- Nitric Oxide
(biosynthesis)
- Rats
- Rats, Sprague-Dawley
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