Abstract | OBJECTIVE: METHODS: A literature search (PubMed) was done from 1995 to the present for randomized controlled trials (RCTs), and a meta-analysis was conducted. RESULTS: Seven RCTs met the criteria, including two of etidronate (ALS and stroke), two of alendronate ( stroke and Parkinson's disease), and three of risedronate ( stroke and Parkinson's disease). All of the RCTs were performed on Japanese patients. According to the results of pooled data analysis, the relative risk (95% confidence interval) of hip fracture in patients receiving etidronate, alendronate, and risedronate treatment compared with placebo or active control treatment was 0.16 (0.03-0.87), 0.29 (0.10-0.80), and 0.24 (0.10-0.58), respectively, suggesting a reduction of risk by more than 70% with oral bisphosphonates. There was no statistical evidence of heterogeneity among RCTs, and publication bias was not identified by the funnel plot and Begg's rank correlation test. No severe adverse events due to oral bisphosphonate treatment were reported. LIMITATION: It remains uncertain whether the findings are relevant for Western patients with an increased risk of hip fracture due to neurological diseases. CONCLUSION:
|
Authors | Jun Iwamoto, Tsuyoshi Takeda, Hideo Matsumoto |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 27
Issue 6
Pg. 1141-8
(Jun 2011)
ISSN: 1473-4877 [Electronic] England |
PMID | 21456887
(Publication Type: Journal Article, Meta-Analysis, Retracted Publication)
|
Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
|
Topics |
- Administration, Oral
- Aged
- Bone Density Conservation Agents
(administration & dosage, adverse effects, therapeutic use)
- Diphosphonates
(administration & dosage, adverse effects, therapeutic use)
- Disabled Persons
- Female
- Hip Fractures
(complications, prevention & control)
- Humans
- Japan
- Male
- Nervous System Diseases
(complications)
- Randomized Controlled Trials as Topic
|