Abstract | PURPOSE: We compared the efficacy and safety of sorafenib in patients with Child-Pugh (CP) class B and CP class A. METHODS: Clinical data from 267 patients with HCC who had been treated with sorafenib were reviewed. Patients were grouped according to CP score (5-6, 7, and 8-9), and their tumor response, tolerance, and survival were assessed. RESULTS: Median patient age was 55 years, and 87.6% were men. Gender, HCC etiology, and extrahepatic metastasis did not differ according to CP score. Of the 225 evaluable patients, 4 achieved partial response and 121 achieved stable disease, making the disease control rate 46.8%. DCR was higher in patients with CP A than CP B score, but did not differ between those with CP scores of 7 and 8-9. The incidence rates of grade 3/4 toxicities did not differ according to CP score. Many patients with CP score 8-9 (26.3%) had to stop sorafenib due to cirrhosis-related complications. At a median follow-up of 15.6 months, the median time to progression and overall survival of all patients were 2.6 and 7.9 months, respectively. OS was greater in patients with CP score 5-6 than in patients with CP scores of 7 or 8-9. CONCLUSIONS:
Sorafenib efficacy and survival outcomes were worse in patients with CP B function. Patients with a CP score of 7 had the same incidence of adverse events and cirrhosis-related complications as those with CP A liver function, suggesting that the former can be included in clinical trials of new agents.
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Authors | Jeong Eun Kim, Baek-Yeol Ryoo, Min-Hee Ryu, Heung-Moon Chang, Dong Jin Suh, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Yoon-Koo Kang |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 68
Issue 5
Pg. 1285-90
(Nov 2011)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 21445543
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Benzenesulfonates
- Phenylurea Compounds
- Pyridines
- Niacinamide
- Sorafenib
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Benzenesulfonates
(adverse effects, therapeutic use)
- Carcinoma, Hepatocellular
(drug therapy)
- Female
- Humans
- Liver Neoplasms
(drug therapy)
- Male
- Middle Aged
- Niacinamide
(analogs & derivatives)
- Phenylurea Compounds
- Pyridines
(adverse effects, therapeutic use)
- Sorafenib
- Treatment Outcome
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