Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes.

Abstract

Intake of whole grains has been associated with lower risks of type 2 diabetes and cardiovascular disease. Brown rice is unrefined whole grain and is produced by removing the outermost layers containing the germ and bran, which are rich in nutrients including dietary fiber, vitamins, minerals, and other unmeasured dietary constituents. The lees of brown rice (LB) are by-products of its fermentation in the process of manufacturing takju, a Korean turbid rice wine. In this study, we hypothesized that intake of LB would reduce waist circumference, a strong risk factor for cardiovascular disease in type 2 diabetic patients. A randomized, double-blind, placebo-controlled study was scheduled for 12 weeks. Thirty subjects were randomly assigned to receive a supplement prepared from the LB or from a mixed-grain dietary product (MG). Body weight, waist circumference, body composition, lipid profiles, and other laboratory parameters were measured. The LB group showed greater reduction in waist circumference (LB: 87.9 ± 8.8 to 85.1 ± 9.0 cm; MG: 86.9 ± 8.8 to 86.0 ± 9.3 cm; P = .032). In addition, the consumption of LB resulted in a significantly greater decrease in the level of aspartate transaminase (LB: 25.4 ± 8.5 to 21.0 ± 5.1 IU/mL; MG: 22.5 ± 5.3 to 22.4 ± 5.7 IU/mL; P = .044) and alanine transaminase (LB: 28.6 ± 11.3 to 21.9 ± 8.2 IU/mL; MG: 24.4 ± 7.5 to 24.5 ± 9.9 IU/mL; P = .038). Consumption of the LB was associated with a decreased waist circumference in type 2 diabetic patients. Further study is required to evaluate the metabolic effect of the extract of the LB in type 2 diabetes.

• Authors: Tae Ho Kim, Eun Kyoung Kim, Min-Seok Lee, Hye-Kyoung Lee, Won Sun Hwang, Sun Jung Choe, Tae-Young Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 31 Issue 2 Pg. 131-8 (Feb 2011) ISSN: 1879-0739 [Electronic] United States
• PMID: 21419317 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Cholesterol, HDL
• Cholesterol, LDL
• Dietary Fiber
• Cholesterol

Topics

• Adult
• Blood Glucose (analysis)
• Body Composition
• Body Weight
• Cardiovascular Diseases (complications)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Dietary Fiber (administration & dosage)
• Dietary Supplements
• Double-Blind Method
• Female
• Glucose Tolerance Test
• Humans
• Male
• Middle Aged
• Oryza (chemistry)
• Risk Factors
• Waist Circumference
• Weight Loss