[The value of brain natriuretic peptide in connective tissue diseases associated with pulmonary arterial hypertension].

Abstract

OBJECTIVE:

To explore the potential role of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the assessment of patients with connective tissue diseases (CTD) associated pulmonary arterial hypertension (PAH).

METHODS:

Thirty patients with CTD associated PAH were evaluated by WHO function, echocardiography, right heart catheterization and blood biomarkers. All the clinical data was analyzed statistically.

RESULTS:

All patients [age (39.5 ± 11.6) yr] were female. Both NT-proBNP and BNP were significantly increased and significantly correlated (all P < 0.05) respectively with mean pulmonary arterial pressure (r = 0.53 and r = 0.40), right arterial pressure (r = 0.55 and r = 0.42), pulmonary vascular resistance (r = 0.69 and r = 0.61), cardiac index (r = -0.58 and r = -0.46), mixed venous blood oxygen saturation (r = -0.62 and r = -0.54), pericardial effusion (r = 0.46 and r = 0.43), right atrial sizes (r = 0.40 and 0.53, and r = 0.39 and 0.45) and right ventricular size (r = 0.55 and r = 0.37). Furthermore, NT-proBNP, but not BNP, significantly correlated with WHO function class (r = 0.55).

CONCLUSION:

Blood NT-proBNP and BNP were elevated in patients with CTD associated PAH and paralleled the extent of function class, pulmonary hemodynamic changes and right ventricular remodeling.

• Authors: Zhuang Tian, Xiao-Xiao Guo, Meng-Tao Li, Qian Wang, Yong-Tai Liu, Jiu-Liang Zhao, Quan Fang, Xiao-Feng Zeng
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 50 Issue 2 Pg. 102-6 (Feb 2011) ISSN: 0578-1426 [Print] China
• PMID: 21418827 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Adult
• Connective Tissue Diseases (complications)
• Familial Primary Pulmonary Hypertension
• Female
• Hemodynamics
• Humans
• Hypertension, Pulmonary (diagnosis, etiology)
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Vascular Resistance
• Ventricular Remodeling