Serum pharmacokinetics of clindamycin hydrochloride in normal dogs when administered at two dosage regimens.

Abstract

The aim of this cross-over study was to compare clindamycin pharmacokinetics in the serum of clinically normal dogs when administered orally at two dosage regimens (5.5 mg/kg, twice daily, and 11 mg/kg, once daily), separated by a 1 week wash-out period. Serum samples were obtained from six clinically normal laboratory beagles before, 3, 6, 9 and 12 h after the first and fifth dose of clindamycin at 5.5 mg/kg, twice daily, and before, 3, 6, 9, 12, 18 and 24 h after the first and third dose at 11 mg/kg, once daily. Serum clindamycin concentrations were determined by reverse-phase liquid chromatography coupled with mass spectrometry. Results were analysed using Student's paired t-test, at a 5% level of significance. Values of pharmacokinetic parameters that differed significantly between the two dosage regimens included the following: maximal concentration and area under the concentration-time curve were higher at 11 mg/kg, once daily, than at 5.5 mg/kg, twice daily; and, more importantly, the ratio of AUC(0-24) to the minimal inhibitory concentration (MIC) value of 0.5 μg/mL for a 24 h period (AUC(0-24)/MIC) was higher when clindamycin was administered at 11 than at 5.5 mg/kg, at least during the first day of drug administration. Therefore, a better pharmacokinetic profile may be expected when clindamycin is administered at 11 mg/kg, once daily, for the treatment of canine pyoderma caused by Staphylococcus pseudintermedius.

• Authors: Manolis N Saridomichelakis, Labrini V Athanasiou, Michel Salame, Manolis K Chatzis, Vassilis Katsoudas, Ioannis S Pappas
• Journal: Veterinary dermatology (Vet Dermatol) Vol. 22 Issue 5 Pg. 429-35 (Oct 2011) ISSN: 1365-3164 [Electronic] England
• PMID: 21418348 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 The Authors. Veterinary Dermatology. © 2011 ESVD and ACVD.

Chemical References

• Clindamycin

Topics

• Animals
• Area Under Curve
• Clindamycin (administration & dosage, blood, pharmacokinetics)
• Cross-Over Studies
• Dogs
• Dose-Response Relationship, Drug
• Female
• Male