Coffee consumption and risk of stroke in women.

Abstract

BACKGROUND AND PURPOSE:

Coffee consumption has been inconsistently associated with stroke incidence and mortality in previous studies. We investigated the association between coffee consumption and stroke incidence in the Swedish Mammography Cohort.

METHODS:

We prospectively followed of 34,670 women without a history of cardiovascular disease or cancer at baseline in 1997. Coffee consumption was assessed in 1997 using a self-administered questionnaire. Incident stroke cases were ascertained from the Swedish Hospital Discharge Registry.

RESULTS:

During a mean follow-up of 10.4 years, we ascertained 1680 stroke events, including 1310 cerebral infarctions, 154 intracerebral hemorrhages, 79 subarachnoid hemorrhages, and 137 unspecified strokes. After adjustment for other risk factors, coffee consumption was associated with a statistically significant lower risk of total stroke, cerebral infarction, and subarachnoid hemorrhage but not intracerebral hemorrhage. The multivariable relative risks of total stroke across categories of coffee consumption (<1 cup/day, 1 to 2 cups/day, 3 to 4 cups/day, and ≥5 cups/day) were 1.00, 0.78 (95% CI, 0.66 to 0.91), 0.75 (95% CI, 0.64 to 0.88), and 0.77 (95% CI, 0.63 to 0.92, respectively; P for trend=0.02). The association between coffee consumption and cerebral infarction was not modified by smoking status, body mass index, history of diabetes or hypertension, or alcohol consumption.

CONCLUSIONS:

These findings suggest that low or no coffee consumption is associated with an increased risk of stroke in women.

• Authors: Susanna C Larsson, Jarmo Virtamo, Alicja Wolk
• Journal: Stroke (Stroke) Vol. 42 Issue 4 Pg. 908-12 (Apr 2011) ISSN: 1524-4628 [Electronic] United States
• PMID: 21393590 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coffee
• Caffeine

Topics

• Adult
• Aged
• Aged, 80 and over
• Caffeine (therapeutic use)
• Cerebral Infarction (drug therapy, epidemiology, prevention & control)
• Coffee
• Cohort Studies
• Female
• Humans
• Middle Aged
• Prospective Studies
• Risk Assessment (methods)
• Risk Factors
• Self Report
• Stroke (drug therapy, epidemiology, prevention & control)
• Subarachnoid Hemorrhage (drug therapy, epidemiology, prevention & control)
• Surveys and Questionnaires (standards)
• Sweden (epidemiology)