Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions.

Abstract

BACKGROUND/AIMS:

Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states.

METHODS:

Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years).

RESULTS:

The dialyzers effectively removed Aβ(1-40) and Aβ(1-42), 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ(1-40)) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages.

CONCLUSIONS:

Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.

• Authors: N Kitaguchi, K Kawaguchi, S Nakai, K Murakami, S Ito, H Hoshino, H Hori, A Ohashi, Y Shimano, N Suzuki, Y Yuzawa, T Mutoh, S Sugiyama
• Journal: Blood purification (Blood Purif) Vol. 32 Issue 1 Pg. 57-62 ( 2011) ISSN: 1421-9735 [Electronic] Switzerland
• PMID: 21346337 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 S. Karger AG, Basel.

Chemical References

• Amyloid beta-Peptides
• Peptide Fragments
• amyloid beta-protein (1-40)
• amyloid beta-protein (1-42)

Topics

• Aged
• Alzheimer Disease (blood, pathology, physiopathology, psychology, therapy)
• Amyloid beta-Peptides (blood, isolation & purification)
• Brain (metabolism, pathology, physiopathology)
• Cognition
• Enzyme-Linked Immunosorbent Assay
• Humans
• Male
• Middle Aged
• Neuropsychological Tests
• Peptide Fragments (blood, isolation & purification)
• Renal Dialysis (statistics & numerical data)