Abstract | BACKGROUND:
Dioscorealide B is an active compound from the rhizome of Dioscorea membranacea Pierre which locally known as "Hua-Khao-Yen". This medicinal plant has long been used in the anticancer prescription of Thai traditional medicine. OBJECTIVE: MATERIAL AND METHOD: RESULTS:
Dioscorealide B showed cytotoxic effect on MCF-7 (IC50 = 2.76 microM) and MDA-MB 468 (IC50 = 9.93 microM). The mRNA level for p53, p21 and Bax were increased while Bcl-2 was decreased after the treatment. MCF-7 treated with Dioscorealide B showed the induction of apoptosis via the activation of caspase-9 and -7. CONCLUSION: The results suggested that the mechanisms of Dioscorealide B might be involved in p53 and the intrinsic apoptotic pathway.
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Authors | Jiraporn Saekoo, Chavaboon Dechsukum, Potchanapond Graidist, Arunporn Itharat |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 93 Suppl 7
Pg. S277-82
(Dec 2010)
ISSN: 0125-2208 [Print] Thailand |
PMID | 21294426
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Heterocyclic Compounds, 4 or More Rings
- Plant Extracts
- dioscorealide B
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Topics |
- Apoptosis
(drug effects)
- Breast Neoplasms
(drug therapy, pathology)
- Cell Line, Tumor
(drug effects)
- Dioscorea
(chemistry)
- Heterocyclic Compounds, 4 or More Rings
(pharmacology, toxicity)
- Humans
- Inhibitory Concentration 50
- Plant Extracts
(pharmacology)
- Plants, Medicinal
- Reverse Transcriptase Polymerase Chain Reaction
- Rhizome
(chemistry)
- Thailand
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