Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population.

Abstract

BACKGROUND:

We sought to examine if polymorphisms in the promoter region of YKL-40 gene (CHI3L1) are associated with serum YKL-40 levels and coronary artery disease (CAD) in Chinese patients.

METHODS:

Three single nucleotide polymorphisms (SNPs) (-329G>A, rs10399931; -247C>T, rs10399805; -131G>C, rs4950928) in the CHI3L1 promoter were determined in 213 consecutive patients with angiographically documented CAD (luminal diameter stenosis ≥50%) and 248 normal controls. Coronary cumulative obstruction score and number of diseased vessels represent the severity of CAD. Serum YKL-40 levels were assessed using an ELISA kit.

RESULTS:

Patients with CAD had remarkably higher serum YKL-40 levels compared to controls (p<0.001). There was no difference in the allele, genotype and haplotype distribution of these three SNPs between controls and CAD patients. The minor alleles of CHI3L1-329G>A and -131G>C were significantly associated with decreased serum YKL-40 levels in both controls (p = 0.001 and p<0.001, respectively) and CAD patients (p = 0.007 and p<0.001, respectively), whereas CHI3L1-247C>T had no appreciable effect. None of these genetic variants and haplotypes was associated with severity of angiographic CAD.

CONCLUSIONS:

CHI3L1-329G>A and -131G>C polymorphisms are associated with serum YKL-40 levels, but not with the prevalence or severity of CAD.

• Authors: Jian Lei Zheng, Lin Lu, Jian Hu, Rui Yan Zhang, Qi Zhang, Qiu Jin Chen, Wei Feng Shen
• Journal: Cytokine (Cytokine) Vol. 54 Issue 1 Pg. 51-5 (Apr 2011) ISSN: 1096-0023 [Electronic] England
• PMID: 21257319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Adipokines
• CHI3L1 protein, human
• Chitinase-3-Like Protein 1
• Glycoproteins
• Lectins

Topics

• Adipokines
• Aged
• Angiography (methods)
• China
• Chitinase-3-Like Protein 1
• Coronary Artery Disease (blood, genetics)
• Female
• Genetic Variation
• Genotype
• Glycoproteins (blood, genetics)
• Haplotypes
• Humans
• Lectins (blood, genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Prevalence
• Promoter Regions, Genetic