[Clinical significance and relationship between HIF-1alpha, COX-2, VEGF and microvessel density expression in laryngeal carcinoma].

Abstract

OBJECTIVE:

To evaluate the role of HIF-1alpha, COX-2, VEGF proteins and Microvessel density in angiogenesis and metastasis of laryngeal carcinoma.

METHOD:

Surgically resected specimens of 64 laryngeal carcinomas were studied by immunohistochemical staining for HIF-1alpha protein, COX-2 protein, VEGF and MVD.

RESULT:

Positive expressions of HIF-1alpha, COX-2 protein and VEGF were found in 65.63%, 68.75% and 71.88% of laryngeal carcinoma specimens, respectively. The mean MVD in this series was 35.79 +/- 9.49. The expression of HIF-1alpha, COX-2 and VEGF positively correlated with MVD expression. There was a positive relationship between HIF-1alpha, COX-2 and VEGF expression. The microvessel density (MVD) in HIF-1alpha, COX-2 and VEGF positive tumors was significantly higher in patients with cervical lymph node metastases than that in patients without metastases.

CONCLUSION:

HIF-1alpha, COX-2 and VEGF proteins may play an important role in the angiogenesis of laryngeal carcinoma. HIF-1alpha regulate the expression and function of its downstream target genes (COX-2 and VEGF), which play a critical role in the angiogenesis of laryngeal carcinoma, metastases in the process of laryngeal cancer cell spreading to cervical lymph nodes.

• Authors: Wei Cheng, Weiguo Zhou
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 24 Issue 18 Pg. 820-2 (Sep 2010) ISSN: 2096-7993 [Print] China
• PMID: 21254648 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hypoxia-Inducible Factor 1, alpha Subunit
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Cyclooxygenase 2
• PTGS2 protein, human

Topics

• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (blood supply, metabolism, pathology)
• Cyclooxygenase 2 (metabolism)
• Female
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
• Laryngeal Neoplasms (blood supply, metabolism, pathology)
• Male
• Microvessels
• Neoplasm Staging
• Neovascularization, Pathologic
• Vascular Endothelial Growth Factor A (metabolism)