[Autochthonous hepatitis E-virus infection as cause of acute hepatitis in Germany - a case report].

Abstract

There is an increasing body of evidence that hepatitis E virus (HEV) triggers acute hepatitis not only in tropical and subtropical regions of Asia, Africa, and America with low sanitary standards but also in highly industrialized countries. We here report on two patients from Thuringia (Germany) with a HEV infection without a recent stay abroad. All other common causes of hepatitis were excluded. Transaminases were significantly increased in both cases, while icterus could be proven in one patient, only. Both patients fully recovered in the long-term course. Epidemiological and phylogenetic data from viral analyses suggest that HEV infection has to be considered as a zoonosis. It is likely that viral transmission from animals to humans occurs through insufficiently cooked meat or entrails, e. g., from pigs or wild animals. In summary, HEV infection is a relevant differential diagnosis in acute non-A/B/C viral hepatitis. Further studies are required for the identification of other transmission pathways, pathogen reservoirs as well as novel concepts for prophylaxis, especially for patients at risk for hepatic diseases.

• Authors: R Veitt, M Reichardt, J Wenzel, W Jilg
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 49 Issue 1 Pg. 42-6 (Jan 2011) ISSN: 1439-7803 [Electronic] Germany
• Vernacular Title: Autochthone Hepatitis-E-Virus-Infektion als Ursache der akuten Hepatitis in Deutschland - eine Kasuistik.
• PMID: 21225537 (Publication Type: Case Reports, English Abstract, Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Acute Disease
• Aged
• Female
• Germany
• Hepatitis E (diagnosis, drug therapy, microbiology)
• Hepatitis E virus (isolation & purification)
• Humans
• Male
• Middle Aged
• Travel
• Treatment Outcome