A retrospective, cohort study.
SETTING: Titration of PEEP based on the lower inflection point of the constant-flow, pressure-volume curve.
MEASUREMENTS AND MAIN RESULTS: Patients were divided into 2 groups based on
PVC-guided PEEP changes of <3 cm H2O (
PVC-NC or "no change") or ≥3 cm H2O (
PVC-CHG or "change") from the initial empiric prescription. There was a greater increase in partial pressure of arterial
oxygen (PaO2)/fractional concentration of inspired
oxygen (FiO2) in the
PVC-CHG group, with a mean change of 80 ± 50 (95% confidence interval [CI] 61, 98) versus 42 ± 54 (95% CI 17, 67) in the
PVC-NC group. Eighty-two percent of patients (41/50) showed an increase in ratio of partial pressure of arterial
oxygen to fraction of inspired
oxygen (PaO2/FiO2) by 20% within 6 to 24 hours after the
PVC test-greater in the
PVC-CHG group (OR 1.44, 95% CI 1.02, 2.01). Thirteen percent (4/30) within the
PVC-CHG group and none within the
PVC-NC group (0/20) required a 25% increase in vasoactive infusion rates (P = .089) in relation to the procedure. Univariate logistic regression showed that
PVC-CHG was significantly associated with a 20% change in PaO2/FiO2 (OR 7.54, 95% CI 1.37, 41.41). Multivariate logistic modeling showed that
PVC-guided PEEP changes of ≥3 cm H2O, age ≤65 years, and pre-
PVC FiO2 ≥ .85 were significantly associated with a 20% increase in PaO2/FiO2 (receiver operator area under the curve = .86).
CONCLUSIONS: In the setting of
acute lung injury, use of the constant-flow, pressure-volume curve to prescribe PEEP appears associated with improvement in oxygenation with limited risk of acute, process-related, cardiopulmonary deterioration.