["Warming yang with pungent and sweet nature" compatibility of Guizhigancao Decoction].

Abstract

OBJECTIVE:

To investigate the pharmacodynamic action and the mechanism of the compatibility of "warming yang with pungent and sweet nature" function in Guizhigancao Decoction.

METHODS:

SD rats were divided randomly into four groups:normal control group, guizhi group, gancao group, and guzhi-gancao group. The function of platelet aggregation and release, the contents of 6-keto-PEG1alpha, TXB, cAMP, cGMP and dissociative calcium ion were detected to verify the effects.

RESULTS:

Guzhi-gancao group had obvious effects on inducing platelet aggregationby inhibiting ADP, decreasing both wet weight and dry weight of thrombus in vitro, increasing thrombosis and the contents of 6-keto-PEG1alpha and decreasing concentrations of cGMP and calcium ion.

CONCLUSION:

Compatibility of Guizhigancao Decoction can enhance the function of invigoration pulse beat through "warming yang with pungent and sweet nature".

• Authors: Ying Lv, Jie Gao
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 33 Issue 8 Pg. 1296-9 (Aug 2010) ISSN: 1001-4454 [Print] China
• PMID: 21213545 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• Fibrinolytic Agents
• Calcium

Topics

• Administration, Oral
• Animals
• Blood Platelets (metabolism)
• Calcium (metabolism)
• Cinnamomum (chemistry)
• Drug Combinations
• Drugs, Chinese Herbal (administration & dosage, chemistry, pharmacology)
• Female
• Fibrinolytic Agents (administration & dosage, chemistry, pharmacology)
• Glycyrrhiza (chemistry)
• Male
• Medicine, Chinese Traditional
• Platelet Aggregation (drug effects)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Thrombosis (prevention & control)