[Effect and mechanism of chimonin on pulmonary hypertention of chronic hypoxia and hypercapnic rats].

Abstract

AIM:

To study the effect of chimonin on chronic hypoxia and hypercapnic pulmonary hypertension and to explore its mechanism.

METHODS:

SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group(B), hypoxic hypercapnia + chimonin group (C). HO-1 and HO-1 mRNA was observed in pulmonary arterioles of rats by the technique of immunohistochemistry and in situ hybridization.

RESULTS:

(1) mPAP was significantly higher in rats of B group than that of A and C group. Differences of mCAP were not significant in three groups. (2) Blood CO concentration was significantly higher in rats of B group than that of A group, it was significantly higher in rats of C group than that of B group. (3) Light microscopy showed that WA/TA (vessel wall area/total area), SMC (the density of medial smooth muscle cell) and PAMT (the thickness of medial smooth cell layer) were significantly higher in rats of B group than those of A and C group. (4) Electron microscopy showed proliferation of medial smooth muscle cells and collagenous fibers of pulmonary arterioles in rats of B group, and chimonin could reverse the changes mentioned above. (5) HO-1 and HO-1 mRNA in pulmonary arterioles was significantly higher in rats of B group than that of A group, they were significantly higher in rats of C group than that of B group.

CONCLUSION:

Chimonin can inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling by further increasing the expression of HO-1 mRNA.

• Authors: Xiao-Ying Huang, Liang-Xing Wang, Ming Li, Shao-Xian Chen, Zheng-Jie Xu, Qun-Ji Wang
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 18 Issue 1 Pg. 75-9 (Feb 2002) ISSN: 1000-6834 [Print] China
• PMID: 21179849 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Drugs, Chinese Herbal
• chimonin
• Heme Oxygenase (Decyclizing)
• Hmox1 protein, rat

Topics

• Animals
• Drugs, Chinese Herbal (pharmacology)
• Heme Oxygenase (Decyclizing) (metabolism)
• Hypercapnia (metabolism, pathology, physiopathology)
• Hypertension, Pulmonary (metabolism, pathology, physiopathology)
• Hypoxia (metabolism, pathology, physiopathology)
• Male
• Rats
• Rats, Sprague-Dawley