F-18 FDG PET/CT findings of a case of sacral nerve root neurolymphomatosis that occurred during chemotherapy.

Abstract

Neurolymphomatosis (NL) is a rare, unique subtype of lymphomatous infiltration of peripheral nerves. Clinical/radiologic diagnosis of NL is challenging. We report F-18 FDG PET/CT findings of a case of breast diffuse large B-cell lymphoma, in which NL developed regardless of regression of systemic lesions during induction chemotherapy. FDG PET/CT showed characteristic findings of well-demarcated, linear abnormal FDG uptake along a sacral vertebral foramen, leading to diagnosis of NL, with the finding of thickened nerve roots on magnetic resonance imaging. Altered chemotherapeutic regimen resulted in disappearance of these abnormal FDG uptake, with recovery of neurologic symptoms. Peripheral nerve NL may occur during chemotherapy, and FDG PET/CT can be a useful imaging modality in diagnosis and monitoring of therapeutic response of this disease.

• Authors: Kazuyoshi Suga, Kawakami Yasuhiko, Naofumi Matsunaga, Toshiaki Yujiri, Tatsuki Nakazora, Kouichi Ariyoshi
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 36 Issue 1 Pg. 73-6 (Jan 2011) ISSN: 1536-0229 [Electronic] United States
• PMID: 21157220 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fluorodeoxyglucose F18

Topics

• Breast Neoplasms (drug therapy)
• Drug-Related Side Effects and Adverse Reactions
• Female
• Fluorodeoxyglucose F18
• Humans
• Lymphoproliferative Disorders (diagnostic imaging, etiology)
• Middle Aged
• Positron-Emission Tomography
• Sacrum (diagnostic imaging, innervation)
• Spinal Nerve Roots (diagnostic imaging)
• Tomography, X-Ray Computed