The protective effect of Schisandra lignans on stress-evoked hepatic metastases of P815 tumor cells in restraint mice.

Abstract

AIM OF THE STUDY:

The present study was conducted to investigate the effects of schisandra lignans extract (SLE) on stress-evoked hepatic metastases of mastocytoma P815 tumor cells, which was closely related with immune function.

MATERIALS AND METHODS:

The high-performance liquid chromatography (HPLC) fingerprint of SLE was recorded and the percentage composition of schisandra lignans was determined as 82.63%. The contributions of the immunomodulatory properties of SLE to the protective effects on stress-induced hepatic metastases were studied.

RESULTS:

Our results found that restraint stress significantly promoted hepatic metastases of P815 tumor cells. However, oral administration of SLE (100 and 200mg/kg/d, 14d) significantly reduced the number of metastatic colonies in liver of restrained mice. SLE was further found to be significantly improving T lymphocyte proportions and increasing cytotoxic T lymphocyte (CTL) activity of immunized spleen cells in stressed mice.

CONCLUSION:

These results indicated that the protective effects of SLE on hepatic metastases were related to its alleviation of the adverse effects of stressors for bio-homeostasis and immunoprotection. The obtained data provided evidences to elucidate the traditional use of Fructus schisandrae as a tonic or sedative.

• Authors: Shu-Hong Tang, Rong-Rong He, Ting Huang, Cong-Zhi Wang, Yun-Feng Cao, Yang Zhang, Hiroshi Kurihara
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 134 Issue 1 Pg. 141-6 (Mar 08 2011) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 21130851 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Lignans
• Plant Extracts
• Malondialdehyde

Topics

• Animals
• Chromatography, High Pressure Liquid
• Female
• Immobilization
• Lignans (pharmacology)
• Liver Neoplasms, Experimental (immunology, prevention & control, secondary)
• Malondialdehyde (metabolism)
• Mastocytoma (immunology, pathology)
• Mice
• Mice, Inbred DBA
• Plant Extracts (pharmacology)
• Schisandra (chemistry)
• Spleen (cytology, drug effects)
• Stress, Physiological
• T-Lymphocyte Subsets
• T-Lymphocytes, Cytotoxic (immunology)