Antilipidemic activity of organic solvent extract from Sorghum bicolor on rats with diet-induced obesity.

Abstract

The present study evaluated the antiobesity and lipid-lowering effects from dichloromethane and ethyl acetate extracts of Hwanggeumchal Sorghum varieties on Sorghum bicolor. The Hwanggeumchal Sorghum ethyl acetate extracts significantly reduced the plasma total cholesterol and triglyceride levels significantly when given orally at a dose of 50 and 300 mg/kg/day to the high-fat diet-induced obese rats for 2 weeks. These findings demonstrate the excellent pharmacological potential of Hwanggeumchal Sorghum varieties to prevent obesity.

• Authors: Ill-Min Chung, Min-A Yeo, Sun-Jin Kim, Myong-Jo Kim, Dong-Sik Park, Hyung-In Moon
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 30 Issue 11 Pg. 1865-8 (Nov 2011) ISSN: 1477-0903 [Electronic] England
• PMID: 21078773 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetates
• Anti-Obesity Agents
• Hypolipidemic Agents
• Lipids
• Plant Extracts
• Solvents
• Methylene Chloride
• ethyl acetate

Topics

• Acetates (chemistry)
• Animals
• Anti-Obesity Agents (therapeutic use)
• Diet, High-Fat
• Hypolipidemic Agents (therapeutic use)
• Lipids (blood)
• Male
• Methylene Chloride (chemistry)
• Obesity (blood, drug therapy)
• Phytotherapy
• Plant Extracts (therapeutic use)
• Rats
• Rats, Wistar
• Solvents (chemistry)
• Sorghum