What is the optimal blood pressure in patients after acute coronary syndromes?: Relationship of blood pressure and cardiovascular events in the PRavastatin OR atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction (PROVE IT-TIMI) 22 trial.

Abstract

BACKGROUND:

Aggressive blood pressure (BP) control has been advocated in patients with acute coronary syndrome, but few data exist in this population relative to cardiovascular outcomes.

METHODS AND RESULTS:

We evaluated 4162 patients enrolled in the PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction (PROVE IT-TIMI) 22 trial (acute coronary syndrome patients randomized to pravastatin 40 mg versus atorvastatin 80 mg). The average follow-up BP (systolic and diastolic) was categorized into 10-mm Hg increments. The primary outcome was a composite of death due to any cause, myocardial infarction, unstable angina requiring rehospitalization, revascularization after 30 days, and stroke. The secondary outcome was a composite of death due to coronary heart disease, nonfatal myocardial infarction, or revascularization. The relationship between BP (systolic or diastolic) followed a J- or U-shaped curve association with primary, secondary, and individual outcomes, with increased events rates at both low and high BP values, both unadjusted and after adjustment for baseline variables, baseline C-reactive protein, and on-treatment average levels of low-density lipoprotein cholesterol. A nonlinear Cox proportional hazards model showed a nadir of 136/85 mm Hg (range 130 to 140 mm Hg systolic and 80 to 90 mm Hg diastolic) at which the incidence of primary outcome was lowest. The curve was relatively flat for systolic pressures of 110 to 130 mm Hg and diastolic pressures of 70 to 90 mm Hg.

CONCLUSIONS:

After acute coronary syndrome, a J- or U-shaped curve association existed between BP and the risk of future cardiovascular events, with lowest event rates in the BP range of approximately 130 to 140 mm Hg systolic and 80 to 90 mm Hg diastolic and a relatively flat curve for systolic pressures of 110 to 130 mm Hg and diastolic pressures of 70 to 90 mm Hg, which suggests that too low of a pressure (especially <110/70 mm Hg) may be dangerous.

CLINICAL TRIAL REGISTRATION:

URL: http://www.clinicaltrials.gov. Unique identifier: NCT00382460.

• Authors: Sripal Bangalore, Jie Qin, Sarah Sloan, Sabina A Murphy, Christopher P Cannon, PROVE IT-TIMI 22 Trial Investigators
• Journal: Circulation (Circulation) Vol. 122 Issue 21 Pg. 2142-51 (Nov 23 2010) ISSN: 1524-4539 [Electronic] United States
• PMID: 21060068 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Heptanoic Acids
• Pyrroles
• Atorvastatin
• Pravastatin

Topics

• Acute Coronary Syndrome (drug therapy, mortality, physiopathology)
• Adult
• Aged
• Anticholesteremic Agents (administration & dosage, adverse effects)
• Atorvastatin
• Blood Pressure (drug effects, physiology)
• Female
• Follow-Up Studies
• Heptanoic Acids (administration & dosage, adverse effects)
• Humans
• Hypertension (mortality, prevention & control)
• Incidence
• Male
• Middle Aged
• Myocardial Infarction (drug therapy, mortality, physiopathology)
• Pravastatin (administration & dosage, adverse effects)
• Prognosis
• Proportional Hazards Models
• Pyrroles (administration & dosage, adverse effects)
• Risk Factors
• Thrombolytic Therapy
• Treatment Outcome