Immunophenotype of nipple adenoma in a male patient.

Abstract

BACKGROUND:

Adenoma of the nipple is rare in men. It must be distinguished from a breast carcinoma and from Paget disease. In this sense, immunohistochemistry can be of some help. In women, for instance, immunoexpression of c-erbB-2 favors a diagnosis of Paget disease, according to some studies. Nevertheless, we have not found any studies on HER2/neu status, estrogen receptors, or progesterone receptors in nipple adenoma of male patients.

METHODS:

We present a case of an adenoma of the nipple in a 21-year-old man in which we carried out a wide immunohistochemical study.

RESULTS:

The lesion did not express estrogen receptors, progesterone receptors, or androgen receptors. The HercepTest was negative. Smooth muscle Actin and p63 were remarked in the basal layer of the tumoral tubules, supporting the benignancy of the lesion.

CONCLUSIONS:

This case of adenoma of the nipple in a male shows an immunophenotype that is similar to the ones reported in female patients.

• Authors: Angel Fernandez-Flores, Jose-Manuel Suarez-Peñaranda
• Journal: Applied immunohistochemistry & molecular morphology : AIMM (Appl Immunohistochem Mol Morphol) Vol. 19 Issue 2 Pg. 190-4 (Mar 2011) ISSN: 1533-4058 [Electronic] United States
• PMID: 21030863 (Publication Type: Case Reports, Journal Article)

Chemical References

• Actins
• Biomarkers, Tumor
• CKAP4 protein, human
• Membrane Proteins
• Receptors, Androgen
• Receptors, Estrogen
• Receptors, Progesterone
• ERBB2 protein, human
• Receptor, ErbB-2

Topics

• Actins (biosynthesis)
• Adenoma (pathology)
• Biomarkers, Tumor (biosynthesis)
• Breast Neoplasms, Male (pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Membrane Proteins (biosynthesis)
• Molecular Typing
• Nipples (pathology)
• Receptor, ErbB-2 (biosynthesis)
• Receptors, Androgen (biosynthesis)
• Receptors, Estrogen (biosynthesis)
• Receptors, Progesterone (biosynthesis)
• Young Adult