[The radiation sensitizing activity of metronidazole and iso-metronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole)].

Abstract

The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.

• Authors: S J Proskurjakov, O A Smoryzanova, N I Rjabcenko, A N Dedenkov
• Journal: Radiobiologia, radiotherapia (Radiobiol Radiother (Berl)) Vol. 31 Issue 6 Pg. 531-6 ( 1990) ISSN: 0033-8184 [Print] Germany
• Vernacular Title: Die radiosensibilisierende Aktivität von Metronidazol und iso-Metronidazol (1-(2-Hydroxyäthyl)-2-Methyl-4-Nitroimidazol).
• PMID: 2101458 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Radiation-Sensitizing Agents
• Metronidazole
• isometronidazole

Topics

• Animals
• Combined Modality Therapy
• Female
• In Vitro Techniques
• Metronidazole (analogs & derivatives, therapeutic use)
• Mice
• Neoplasms, Experimental (drug therapy, radiotherapy)
• Radiation-Sensitizing Agents (therapeutic use)