Abstract |
The rheological behavior and clearance of bronchial mucus samples collected by protected expectoration from 24 out-patients with simple chronic bronchitis were investigated before, at the end of a short period of treatment (4 days) with a single oral dose of 2.7 g (sachet) of carbocysteine-lysine (evening meal), and on the 4th and 8th days after the end of treatment versus placebo. In the group treated with carbocysteine-lysine, there were significant reductions in viscosity (-67, -48, -62%) and increases in mucociliary transport (+41, +31, +34%) at the three times mentioned. The most striking finding was that the improvements were still present 8 days after cessation of treatment. The elasticity parameter was not affected in any statistically significant way (-10, -24, +65%). These findings suggest the presence of some type of 'post-mucoactive' effect.
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Authors | P C Braga, L Allegra, C Rampoldi, A Ornaghi, G Beghi |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 57
Issue 6
Pg. 353-8
( 1990)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 2099568
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Bronchitis
(metabolism)
- Carbocysteine
(pharmacokinetics)
- Chronic Disease
- Female
- Humans
- Male
- Middle Aged
- Mucociliary Clearance
- Mucus
(metabolism)
- Random Allocation
- Rheology
- Viscosity
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